Office: O2 13W13
Pharmacology, neurodegenerative diseases, treatment, protein aggregation, neuroprotection
I started my scientific carreer in 1985 as Clinical Research Fellow at the Department of Internal Medicine of the VUMC, and switched in 1987 to the Department of Neurology of the VUMC, where I worked until 1991 on my PhD thesis investigating dopamine receptor coupled signal transduction mechanisms.
post-doc year: After obtaining my PhD degree, I spent one year as a post-doctoral fellow at the Department of Psychiatry of the Valerius clinic in Amsterdam studying the neuroinflammatory response in Alzheimer’s disease
At the VUMC Neurology department I worked on the role of oxidative stress and protein misfolding in the pathogenesis of Parkinson’s disease. In 2000, I moved to the Department of Medical Pharmacology of the VUMC to become head of the Neuropharmacology group. In this capacity, my research interests broadened to include investigation of the role of neuroinflammatory factors in the pathogenesis of neurodegenerative disorders, in particular Parkinson’s disease, Alzheimer’s disease and Multiple Sclerosis.
Currently, the Neuropharmacology section consists of 10 people, including two other tenured neuroscientists and a number of Ph.D. students funded by both institutional and external grants. My scientific production consists of (co-)authorship of more than 70 papers in international peer-reviewed journals in the fields of Pharmacology, Biology of Oxidative Stress and Neurochemistry.